MG AICA-Riboside 1PC x 50MG

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargetAdenosine monophosphate-activated protein kinase (AMPK)

Cell permeable: yes

General description

A cell-permeable nucleoside compound that is processed intracellularly to form a phosphorylated metabolite, which activates adenosine monophosphate-activated protein kinase (AMPK) without disrupting the cellular concentrations of ATP, ADP, or AMP. Also acts as a regulator of de novo purine synthesis. Stimulates glucose uptake in both perfused and isolated muscle. AICAr-stimulated glucose transport is not affected by Wortmannin (Cat. No. 681675), a PI-3K inhibitor. Shown to inhibit the synthesis of triacylglycerol (TAG), diacylglycerol (DAG), and phospholipid, probably as a result of AMPK activation and the subsequent inhibition of sn-glycerol-3-phosphate acyltransferase (GPAT) by AMPK. Also reported to inhibit Hsp90 chaperone function. Imparts protection against cell death induced by glucose deprivation, chemical hypoxia, and exposure to glutamate and amyloid β (Aβ) peptide.

A cell-permeable nucleoside compound whose phosphorylated metabolite activates adenosine monophosphate-activated protein kinase (AMPK) and acts as a regulator of de novo purine synthesis. Stimulates glucose uptake in perfused and isolated muscle. Offers protection against cell death induced by glucose deprivation, chemical hypoxia, and exposure to glutamate and Aβ peptide.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Meli, M., et al. 2006. J. Med. Chem.in press.Culmsee, C., et al. 2001. J. Mol. Neurosci.17, 45.Muoio, D.M., et al. 1999. Biochem. J.338, 783.Hayashi, T., et al. 1998. Diabetes47, 1369.Corton, J.M., et al. 1995. Eur. J. Biochem.229, 558.

Packaging

Packaged under inert gas

50 mg in Plastic ampoule

Preparation Note

May require heating to 50°C to achieve complete solubilization in methanol.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)